• BioMAN Laboratory

    Biomolecular Mechanics And Nanotechnology Laboratory

  • Our Science

    Biomolecular Mechanics

    "Everything in biology is mechanical." – Julio Fernandez

     

    The importance of mechanical forces in cell biology, in addition to chemical and genes, is increasingly appreciated.

     

    The BioMAN Lab is interested in uncovering the fundamental physical forces that govern how cells generate, detect, and respond to mechanical forces at the molecular level. We are using DNA origami scaffolds, protein engineering, tension sensing peptides, super-resolution microscopy, and cryoEM techniques to measure tension in vitro and in vivo.

    Biomolecular Nanotechnology

    "What I cannot create, I do not understand." – Richard Feynman

     

    Our lab is using DNA nanostructures to reconstruct mechanically-functional biomolecular systems while capturing their spatial and mechanical contexts.

    These biologically, spatially, and mechanically-relevant reconstituted systems are amenable to mathematically-rigorous, physically-sound, and highly-predictive modeling.

    The Mechanobiology of Malaria Parasite Invasion

    The initial theme of our lab will focus on the mechanical interactions that power and guide malaria parasite invasion. Malaria, an infectious disease caused by deadly Plasmodium parasites, is a global health concern. In 2013, malaria was responsible for ~200 million cases and claimed >500,000 lives, which is equivalent to ~1 death per minute.

    Finally, our lab will put these knowledge to work. From the biomedical translational standpoint, we envision the reconstituted system as the base of low-cost high-throughput drug screening tools for malaria remedies that target unique biophysical features of malaria host-cell invasion. With respect to technology development, the proposed research program will also develop transformative molecular tools that can be broadly used to dissect other systems in molecular biology.

  • Our Recent Papers

    RIZAL F HARIADI, ERIK WINFREE, AND BERNARD YURKE

    PNAS 2015, 112 (45), E6086-E6095

     

    "And so he looked at a tiny bubble
    bursting on the surface of an infinite ocean.
    Within it, molecules, their world torn asunder.
    And in that vigor,
    and in that endless churning,
    the origin of life.
    We followed him deep into this vision
    ."

    – Erik Winfree

    RIZAL F HARIADI, RF SOMMESE, AS ADHIKARI, RE TAYLOR, S SUTTON, JA SPUDICH, ANAD S SIVARAMAKRISHNAN

    Nature Nanotechnology 2015, 10 (8), 696-700

    YEE H TEE, TOM SHEMESH, VISALATCHI THIAGARAJAN, RIZAL F HARIADI, KAREN L ANDERSON, CHRISTOPHER PAGE, NIELS VOLKMANN, DORIT HANEIN, SIVARAJ SIVARAMAKRISHNAN, MICHAEL M KOZLOV, AND ALEXANDER D BERSHADSKY

    Nature Cell Biology 2015, 17 (4), 445-457

    RIZAL F HARIADI, MARIO CALE, AND SIVARAJ SIVARAMAKRISHNAN

    PNAS 2014, 111 (11), 4091-4096

    More papers 

    BAM! POW!

  • Who we are

    Rizal F. Hariadi

     

    Assistant Professor in Physics

    Ph.D. – Caltech

    Franky Djutanta

     

    Incoming Ph.D. student

    M.Sc. – Institut Teknologi Bandung

    Tunjung "TJ" Mahatmanto

    Postdoc

    Ph.D. – University of Queensland

    Rishabh M. Shetty

     

    Ph.D. student

    ASU Biomedical Engineering

    Shuoxing Jiang
     

    Postdoc

    (co-advised with Hao Yan)

    Ph.D. – ASU

    Swarup Dey
     

    Ph.D. student

    (co-advised with Hao Yan)

    ASU School of Molecular Sciences

    Isyatul "Zee" Azizah

     

    Summer researcher

    B.Sc. – Brawijaya

    Gde Bimananda Mahardika Wisna

    Summer researcher

    B.Sc. – Institut Teknologi Bandung

    Gaby Almira
     

    Summer researcher

    M.Sc. – Osaka

    Emilio Bachtiar
     

    Incoming Summer researcher

    M.Sc. student – Johns Hopkins

    Alexander DaSilva
     

    Barret Honors Fellow

    ASU

    Anshuman Bakshi

     

    Summer researcher

    B.Sc student – Berkeley

  • Current and Former Visitors

    James "Bo" Faust

     

    Frequent Visitor

    Ph.D - Arizona State University

    Bernard "Bernie" Yurke

    Former Visitor

    Boise State University

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  • Lab News

    The latest updates from the BioMAN Lab

  • Join Us!

    The BioMAN Lab is seeking for independent, highly-motivated

    undergraduate students, graduate students and post-docs 

    from different branches of science, engineering, and art.

  • Get in touch!

     Email or drop us a note below

  • Where we are

    The Biodesign Institute A (BDA), Arizona State University

  • Presentation Slides

    To upload your slides for group/sub-group meetings, click UPLOAD button below. Check your email for password.

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